The aerobic carbohydrate metabolism of leukocytes in health and leukemia. I. Glycolysis and respiration.
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منابع مشابه
The aerobic carbohydrate metabolism of leukocytes in health and leukemia. II. The effect of various substrates and coenzymes on glycolysis and respiration.
data were presented on the aerobic carbohydrate metabolism of homog enates of leukocytes isolated from normal (N), chronic myelocytic leukemic (CML), and chronic lymphatic leukemic (CLL) bloods. It was shown that with glucose and hexose diphosphate (HDP) as substrates, oxygen consumption, glucose utiliza tion, and lactic acid production were significantly higher in N than in CML and CLL homogen...
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R EPEATED INVESTIGATIONS on the nature of the carbohydrate metabolism of mammalian leukocytes have resulted in a large body of conflicting data. Until recently it was generally felt that leukocytes derived most of their energy from glycolysis.12 This conclusion was drawn because a high rate of aerobic glycolysis was usually observed in leukocytes and because their cellular ATP levels were much ...
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With the technical assistance of Clarence Ellis M ANY DIVERGENT RESULTS have been published concerning the energy metabolism of human leukemic leukocytes. This subject has been extensively reviewed by Seelich.’ Leukemic lymphocytes have variously been reported to have low or absent aerobic glycolysis, low to high respiration, and low to high anaerobic glycolysis. Leukemic granulocytes have been...
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One of the unique characteristics of polymorphonuclear leukocytes from normal subjects is their high rate of aerobic and anaerobic glycolysis with accumulation of lactic acid (1,2). Intermediates and enzymes of the Embden-Meyerhof scheme have been isolated and identified (3-5) and Beck (6) has calculated the V,,, of a number of these enzymes. The results indicate the hexokinase to be the chief ...
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A L T H O U G H there is considerable evidence that carbohydrate metabolism plays an important part in the process of cell division (see Bullough, 1952), conclusions have differed regarding the relative importance of glycolysis and catabolism involving respiration. In the adult mouse epidermis Bullough & Johnson (1951) found that cell division was dependent upon the respiratory oxidation of pyr...
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ورودعنوان ژورنال:
- Cancer research
دوره 12 11 شماره
صفحات -
تاریخ انتشار 1952